Front Cover: MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L (ChemMedChem 1/2022)

The Front Cover shows that MPI8, a SARS-CoV-2 main protease inhibitor, dually inhibits human cathepsin L to prevent the RNA genome from leaving endosome. MPI8 is reversible covalent inhibitor of displays high potency in inhibiting virus vitro. It also selectively over other tested cathepsins. design by Dr. Xinyu Ma. More information can be found Full Paper R. Ma, Shiqing Xu, Wenshe Ray Liu et al.